personal photo of Elena Winheim

Elena Winheim

Tagline:A Walter Benjamin Fellow exploring how the skin’s immune landscape forms in childhood through high-resolution approaches including scRNA-seq and spatial transcriptomics.

Cambridge, Vereinigtes Königreich

Research Interests

  • Immunology
  • Computational Biology
  • Skin development
  • Aging
  • Infectious diseases

About Me

I am a research scientist and Walter Benjamin Fellow fascinated by how barrier tissues—especially the skin—build and maintain immune protection throughout life.

My work focuses on uncovering how the skin’s immune system develops during childhood and how early-life events shape long-term immune trajectories. I combine high-resolution technologies such as single-cell RNA sequencing (scRNA-seq) , spatial transcriptomics , and computational analysis in R and Python with flow cytometry and experimental dermatology.

With a background in virology and immunology, my broader vision is to chart the cellular and spatial architecture of developing skin—from stem cells to immune niches—to understand how barrier tissues sense, adapt, and learn over time.

Why this matters:
The skin is our largest immune organ, yet we still know little about how its defences are built in early life—a critical window that shapes immunity for decades. By understanding how paediatric skin develops resilience (or vulnerability), we can pave the way for earlier diagnosis and better treatments for inflammatory, infectious, and genetic skin diseases.

Ultimately, I aim to reveal how early immune maturation influences lifelong health, bridging developmental biology, immunology, and computational science. 🚀

First-author Publications

  • Interferon-induced activation of dendritic cells and monocytes by yellow fever vaccination correlates with early antibody responses

    Journal ArticlePublisher:Proceedings of the National Academy of Sciences of the United States of AmericaDate:2025
    Authors:
    Elena WinheimAntonio Santos-PeralTamara EhmLinus RinkeSandra RiemerM. ZauchaSebastian GoreschLisa LehmannKatharina EisenächerM. PritschG. Barba-SpaethTobias StraubS. RothenfusserAnne B. Krug
  • RIG-I-like receptor-dependent type I Interferon regulates antigen dose and activation in yellow fever vaccine 17D-infected antigen presenting cells

    Journal ArticlePublisher:bioRxivDate:2025
    Authors:
    M. ZauchaElena WinheimAntonio Santos-PeralApurva DhavalePaul SchwarzlmuellerFrank DahlstroemGiulia SpielmannMagdalena K. ScheckLinus RinkeYiqi HuangVarvara ArzhakovaKatharina EisenächerHadi KarimzadehM. PritschJulia SpanierU. KalinkeJulia Thorn-SesholdG. Barba-SpaethS. RothenfusserAnne B. Krug
  • A prenatal skin atlas reveals immune regulation of human skin morphogenesis

    Journal ArticlePublisher:NatureDate:2024
    Authors:
    N. GopeeElena WinheimB. OlabiChloe AdmaneA. FosterNi HuangR. BottingFereshteh TorabiD. SumanaweeraAnh Phuong LeJin KimLuca VergerEmily StephensonDiana AdãoClarisse GânierKelly Y. GimSara A. SerdyCiCi DeakinIssac GohLloyd SteeleKarl AnnusverMohi-Uddin MiahWin TunPejvak MoghimiKwasi KwakwaTong LiDaniela Basurto LozadaBen RumneyCatherine TudorKenny RobertsNana-Jane ChipampeKeval SidhpuraJustin EnglebertLaura JardineGary ReynoldsAntony RoseVicky RoweS. PritchardI. MulasJ. FletcherDorin-Mirel PopescuElizabeth PoynerAnna DuboisA. GuyAndrew FilbyS. LisgoRoger A. BarkerIan A. GlassJong-Eun ParkR. Vento-TormoM. NikolovaPeng HeJ. E. LawrenceJosh MooreS. BallereauChristine B HaleV. ShanmugiahDave HorsfallNeil RajanJ. McGrathEdel A. O’TooleBarbara TreutleinO. BayraktarMaria KasperF. ProgatzkyPavel MazinJiyoon LeeL. GambardellaKarl R. KoehlerSara A TeichmannM. Haniffa
  • Distinct and dynamic activation profiles of circulating dendritic cells and monocytes in mild COVID‐19 and after yellow fever vaccination

    Journal ArticlePublisher:European Journal of ImmunologyDate:2022
    Authors:
    Elena WinheimT. EserF. DéakMohamed I. M. AhmedO. BaranovLinus RinkeKatharina EisenächerAntonio Santos-PeralH. KarimzadehM. PritschC. SchererM. MuenchhoffJ. HellmuthMichael von Bergwelt-BaildonLaura OlbrichM. HoelscherA. WieserI. KroidlS. RothenfusserC. GeldmacherA. Krug
  • Impaired function and delayed regeneration of dendritic cells in COVID-19

    Journal ArticlePublisher:PLoS PathogensDate:2021
    Authors:
    Elena WinheimLinus RinkeKonstantin LutzA. ReischerA. LeutbecherLina WolframLisa RauschJ. KranichP. R. WratilJohanna E. HuberDirk BaumjohannS. RothenfusserJ. HellmuthC. SchererM. MuenchhoffM. Bergwelt-BaildonK. StarkT. StraubT. BrockerO. KepplerM. SubkleweA. Krug

Public Outreach

  • Teaching course in spatial transcriptomics

    Date: Jan 2025

  • Radio Interview

    Date: Dec 2024

    Description:

    Canadian Radio Quirks and Quarks interview on Human cell atlas Initiative, together with Aviv Regev.

  • Webatlas of prenatal skin

    Date: Aug 2024

    Event name: Prenatal skin .

    Description:

    Explore the prenatal skin single-cell transcriptomics and spatial transcriptomics data here!

  • Skinvaders Computer Game

    Date: Jan 2024

Education

  • PhD in medical research

    from: 2017, until: 2022

    Field of study:ImmunologySchool:Ludwig-Maximilians-UniversitätLocation:Munich, Germany

  • Master of Science in molecular medicine

    from: 2015, until: 2017

    Field of study:Immunology, Infectious diseasesSchool:Eberhard-Karls-UniversitätLocation:Tübingen, Germany

  • Bachelor of Science in molecular medicine

    from: 2011, until: 2015

    Field of study:Molecular MedicineSchool:Eberhard-Karls-UniversitätLocation:Tübingen, Germany